Document 0644
 DOCN  M9480644
 TI    Continued drug use and other cofactors for progression to AIDS among
       injecting drug users.
 DT    9410
 AU    Ronald PJ; Robertson JR; Elton RA; Edinburgh Drug Addiction Study,
       University of Edinburgh,; Scotland, UK.
 SO    AIDS. 1994 Mar;8(3):339-43. Unique Identifier : AIDSLINE MED/94304554
 AB    OBJECTIVE: To evaluate the effects of continued drug use and other
       cofactors on progression to AIDS among HIV-infected injecting drug
       users. DESIGN: A prospective study. SETTING: The Muirhouse Medical Group
       in Edinburgh, Scotland, UK. SUBJECTS: A total of 156 HIV-infected
       injecting drug users. MAIN OUTCOME MEASURES: Progression to AIDS and low
       absolute CD4 counts. RESULTS: Of this group, 48% will have progressed to
       AIDS 10 years after seroconversion. Age and low absolute T4 counts had a
       significant effect on progression to AIDS, with older patients
       progressing more rapidly. Sex had no significant effects on progression.
       Absolute CD4+ counts and the CD4:CD8 ratio were significant predictors
       of progression among the group. Concurrent heroin injecting increased
       the risk of progression to AIDS. No significant effects were observed
       for use of other drugs. CONCLUSIONS: Our findings suggest that continued
       drug use may have an accelerating effect on progression to AIDS. Age
       also had an accelerating effect on progression, but sex had no
       significant effects. In general, the study group did not appear to
       progress at a different rate from other similar groups of HIV-infected
       individuals, despite the fact that this was a relatively young cohort.
       These data were based on accurate estimates of seroconversion dates.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/EPIDEMIOLOGY/*ETIOLOGY
       Adolescence  Adult  Age Factors  Cohort Studies  CD4-CD8 Ratio  Female
       Human  HIV Infections/BLOOD/*COMPLICATIONS  Leukocyte Count  Male
       Proportional Hazards Models  Prospective Studies  Risk Factors
       Scotland/EPIDEMIOLOGY  Substance Abuse, Intravenous/*COMPLICATIONS
       Support, Non-U.S. Gov't  Time Factors  T4 Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).